MOTS-c Peptide | 5mg | Research Grade

MOTS-c peptide is a mitochondrial open reading
frame of the 12S rRNA-c peptide, a novel
mitochondrial derived peptide consisting of
16 amino acids. MOTS-c peptide represents one
of the most exciting developments in
mitochondrial biology research, being the
first mitochondrial derived peptide shown
to act as a systemic hormonal regulator in
research models. The discovery of MOTS-c
peptide challenged the traditional understanding
of mitochondrial function and opened new
avenues for studying mitochondrial derived
signalling in metabolic research.

TECHNICAL SPECIFICATIONS

Molecular Formula: C95H170N34O28S
Molecular Weight: 2174.67 g/mol
Purity: ≥99% by HPLC
Appearance: White lyophilised powder
Storage: Store at -20°C
CAS Number: 1627580-64-6
Sequence: CRQGSIWDTASKMYS (16 amino acids)

ABOUT MOTS-c PEPTIDE RESEARCH

MOTS-c has been extensively studied
in mitochondrial biology, metabolic research
and longevity science environments. As a
mitochondrial derived peptide, MOTS-c targets
the folate cycle and de novo purine biosynthesis
pathways in research models making it uniquely
valuable for studying metabolic regulation
and cellular energy homeostasis.

Research involving MOTS-c has been
published across multiple peer reviewed journals
covering mitochondrial biology, metabolic
research and ageing science. Studies have
examined MOTS-c peptides role in AMPK
activation, insulin sensitivity pathways and
metabolic flexibility in controlled research
environments.

The mechanism of action of MOTS-c  in
research models involves nuclear translocation
in response to metabolic stress. Under conditions
of metabolic challenge, MOTS-c
translocates from the cytoplasm to the nucleus
where it regulates gene expression related to
metabolic adaptation. This nuclear signalling
capacity distinguishes MOTS-c peptide from
other mitochondrial peptides and makes it
valuable for studying the crosstalk between
mitochondrial function and nuclear gene
regulation.

MOTS-c peptide is unique among mitochondrial
derived peptides in that it is encoded by a
small open reading frame within the 12S
ribosomal RNA gene of the mitochondrial genome.
This origin is significant because the
mitochondrial genome typically encodes only
proteins involved in oxidative phosphorylation.
The discovery that the mitochondrial genome
encodes a systemic signalling peptide has
expanded our understanding of mitochondrial
biology considerably.

LONGEVITY AND METABOLIC RESEARCH

MOTS-c peptide is frequently studied alongside
NAD+ and Epithalon peptide in longevity and
mitochondrial biology research settings. These
compounds target complementary aspects of
mitochondrial function and cellular ageing
making combined research protocols particularly
informative. MOTS-c specifically
addresses the signalling role of mitochondria
as endocrine organs while NAD+ addresses the
metabolic fuel aspect of mitochondrial function.
Both are available from PeptideCores.

PURITY AND QUALITY ASSURANCE

Every batch of MOTS-c peptide supplied by
PeptideCores undergoes rigorous independent
third-party testing. HPLC testing confirms
purity at 99% or above. Mass spectrometry
confirms molecular identity of this
mitochondrial derived peptide. Full Certificate
of Analysis issued for every batch.

STORAGE AND HANDLING

Store MOTS-c peptide at minus 20 degrees
Celsius away from direct light and moisture.
Stable for up to 24 months. Once reconstituted
store at 4 degrees Celsius and use within
appropriate research timelines.

WHY CHOOSE PEPTIDECORES FOR MOTS-c

PeptideCores supplies MOTS-c peptide exclusively
for laboratory and research purposes. Each order
includes a Certificate of Analysis. Worldwide
discreet shipping on every order with full
tracking.

ORDERING AND SHIPPING

MOTS-c peptide orders are processed within
24 hours of payment confirmation. Worldwide
discreet shipping with full tracking. No
reference to contents on outer packaging.

FREQUENTLY ASKED QUESTIONS

What is the purity of your MOTS-c peptide?
Our MOTS-c peptide is HPLC verified at 99%
plus purity with a full Certificate of Analysis
included with every order dispatched.

What makes MOTS-c unique?
MOTS-c peptide is the first identified
mitochondrial derived peptide to act as a
systemic hormonal regulator. It is encoded
by a small open reading frame in the
mitochondrial 12S rRNA gene making it
unique among known bioactive peptides.

How does MOTS-c peptide relate to ageing?
Research has shown MOTS-c levels
decline with age in certain research models.
Studies examining MOTS-c peptides role in
metabolic flexibility and AMPK activation
have made it relevant to longevity biology.

How should MOTS-c  be stored?
Store lyophilised MOTS-c  at minus
20 degrees Celsius away from direct light
and moisture. Stable for up to 24 months.

DISCLAIMER

This product is intended for laboratory research
purposes only. It is not intended for human or
veterinary use, diagnosis, treatment or prevention
of any condition or disease. Only qualified
researchers should handle this compound.